Evasin

Family of proteins produced by ticks From Wikipedia, the free encyclopedia

Evasins are a family of salivary proteins produced in parasitic ticks which are capable of shutting off the first steps of an immune response brought about by chemokines.[1] These proteins are injected into a tick's host to prevent a painful inflammation that might otherwise alert the host to the tick's presence. As chemokines have been implicated in a number of inflammatory diseases including atherosclerosis, asthma, rheumatoid arthritis, and cancer, chemokine-binding proteins such as evasins are being researched to assess their therapeutic potential as chemokine-targeting antagonists.[2]

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Evasin-4
Identifiers
OrganismRhipicephalus sanguineus
SymbolEva1
UniProtP0C8E9
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StructuresSwiss-model
DomainsInterPro
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The same term is also used to refer to other proteins.

Tick evasins

The brown dog tick evasin-4 binds to CCL5 and CCL11, but appears to neutralize even more chemokines.[3] It has an Ig-fold domain. Other evasins in this organism include Evasin-1 (P0C8E7) and Evasin-3 (P0C8E8).[1]

Other evasins

Evasin is also used to refer to any viral proteins used for the evasion of the immune responses. This usage is rare.[4]

The term is also used to refer to "Endogenous VASopeptidase INhibitors" (Q9PW56), a kind of endogenous brain protein found in snakes.

References

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