Exaprolol Chemical compound
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Exaprolol is a beta-adrenoceptor antagonist .[ 1]
Quick facts Names, Identifiers ...
Exaprolol
Names
IUPAC name
1-(2-Cyclohexylphenoxy)-3-(propan-2-ylamino)propan-2-ol
Other names
Esprolol
Identifiers
ChemSpider
KEGG
UNII
InChI=1S/C18H29NO2/c1-14(2)19-12-16(20)13-21-18-11-7-6-10-17(18)15-8-4-3-5-9-15/h6-7,10-11,14-16,19-20H,3-5,8-9,12-13H2,1-2H3
Key: ABXHHEZNIJUQFM-UHFFFAOYSA-N
CC(C)NCC(COC1=CC=CC=C1C2CCCCC2)O
Properties
C 18 H 29 N O 2
Molar mass g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25
°C [77
°F], 100
kPa).
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Exaprolol synthesis[ 2]
Van Waarde, A; Doorduin, J; De Jong, JR; Dierckx, RA; Elsinga, PH (2008). "Synthesis and preliminary evaluation of (S)-11C-exaprolol, a novel beta-adrenoceptor ligand for PET". Neurochemistry International . 52 (4– 5): 729– 33. doi :10.1016/j.neuint.2007.09.009 . PMID 17961850 . Carissimi, M; Gentili, P; Grumelli, E; Milla, E; Picciola, G; Ravenna, F (1976). "Basic ethers of cyclohexylphenols with beta-blocking activity: Synthesis and pharmacological study of exaprolol". Arzneimittel-Forschung . 26 (4): 506– 16. PMID 8056 .
