Exosome component 4

EXOSC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Identifiers
Aliases	EXOSC4, RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A, Exosome component 4
External IDs	OMIM: 606491; MGI: 1923576; HomoloGene: 6017; GeneCards: EXOSC4; OMA:EXOSC4 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,080,648 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,214,877 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; mucosa of transverse colon; ; apex of heart; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; right lobe of liver; ; gonad;
	Top expressed in
	embryo; ; right kidney; ; otic placode; ; yolk sac; ; embryo; ; proximal tubule; ; otic vesicle; ; medial ganglionic eminence; ; facial motor nucleus; ; ankle joint;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; exoribonuclease activity; 3'-5'-exoribonuclease activity; RNA binding; mRNA 3'-UTR AU-rich region binding;
Cellular component	cytoplasmic exosome (RNase complex); nuclear exosome (RNase complex); cytoplasm; exosome (RNase complex); nucleolus; nucleus; nucleoplasm; cytosol; intermediate filament cytoskeleton;
Biological process	defense response to virus; rRNA 3'-end processing; rRNA catabolic process; polyadenylation-dependent snoRNA 3'-end processing; U4 snRNA 3'-end processing; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; positive regulation of cell growth; nuclear-transcribed mRNA catabolic process; DNA deamination; maturation of 5.8S rRNA; regulation of mRNA stability; nuclear mRNA surveillance; exonucleolytic catabolism of deadenylated mRNA; histone mRNA catabolic process; rRNA processing; RNA phosphodiester bond hydrolysis, exonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	54512
	109075
	ENSG00000178896
	ENSMUSG00000034259
	Q9NPD3
	Q921I9
	NM_019037
	NM_175399
	NP_061910
	NP_780608
	Wikidata
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