FBXW10

F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.^[5][6][7]

AliasesFBXW10, Fbw10, HREP, SM25H2, SM2SH2, F-box and WD repeat domain containing 10

External IDsOMIM: 611679; MGI: 3052463; HomoloGene: 32757; GeneCards: FBXW10; OMA:FBXW10 - orthologs

Chr.Chromosome 17 (human)^[1]

End18,779,349 bp^[1]

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FBXW10
Identifiers
Aliases	FBXW10, Fbw10, HREP, SM25H2, SM2SH2, F-box and WD repeat domain containing 10
External IDs	OMIM: 611679; MGI: 3052463; HomoloGene: 32757; GeneCards: FBXW10; OMA:FBXW10 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p11.2 Start 18,744,026 bp[1] End 18,779,349 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B2 Start 62,737,895 bp[2] End 62,768,291 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis olfactory zone of nasal mucosa right uterine tube right adrenal cortex cerebellar hemisphere right hemisphere of cerebellum right lobe of liver gastrocnemius muscle Top expressed in seminiferous tubule spermatid spermatocyte embryo zygote secondary oocyte embryo thymus primary oocyte visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin-protein transferase activity Cellular component cytosol Biological process protein polyubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10517 213980 Ensembl ENSG00000171931 ENSMUSG00000090173 UniProt Q5XX13 Q5SUS0 RefSeq (mRNA) NM_001267585 NM_001267586 NM_031456 NM_001033669 NM_001291441 RefSeq (protein) NP_001254514 NP_001254515 NP_001028841 NP_001278370 NP_001391704 NP_001391705 NP_001391706 NP_001391707 Location (UCSC) Chr 17: 18.74 – 18.78 Mb Chr 11: 62.74 – 62.77 Mb PubMed search [3] [4]
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Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM]^[7] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1, ATR kinases (Chaturvedi and ParnaiK, 2010, PMID 20498703).