FLOT2

FLOT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WIN
Identifiers
Aliases	FLOT2, ECS-1, ECS1, ESA, ESA1, M17S1, flotillin 2
External IDs	OMIM: 131560; MGI: 103309; HomoloGene: 3293; GeneCards: FLOT2; OMA:FLOT2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,897,733 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	77,951,260 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; spleen; ; blood; ; gastric mucosa; ; apex of heart; ; olfactory zone of nasal mucosa; ; lymph node; ; minor salivary glands; ; right lung;
	Top expressed in
	ankle joint; ; external carotid artery; ; facial motor nucleus; ; internal carotid artery; ; tunica media of zone of aorta; ; granulocyte; ; dorsomedial hypothalamic nucleus; ; motor neuron; ; carotid body; ; tibiofemoral joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protease binding; protein binding; protein heterodimerization activity; ionotropic glutamate receptor binding;
Cellular component	vesicle; endosome; membrane; cell-cell contact zone; focal adhesion; endocytic vesicle; acrosomal membrane; flotillin complex; uropod; basolateral plasma membrane; apical plasma membrane; cortical actin cytoskeleton; perinuclear region of cytoplasm; caveola; membrane raft; extracellular exosome; cytoplasmic vesicle; lamellipodium; plasma membrane; dendrite cytoplasm; synapse; glutamatergic synapse; anchored component of presynaptic active zone membrane;
Biological process	positive regulation of establishment of T cell polarity; regulation of toll-like receptor 3 signaling pathway; regulation of heterotypic cell-cell adhesion; protein stabilization; negative regulation of amyloid precursor protein catabolic process; negative regulation of gene expression; protein localization to plasma membrane raft; cell adhesion; membrane raft assembly; regulation of myoblast differentiation; epidermis development; protein localization to plasma membrane; anterograde dendritic transport; regulation of postsynaptic membrane neurotransmitter receptor levels; positive regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	2319
	14252
	ENSG00000132589
	ENSMUSG00000061981
	Q14254
	Q60634
	NM_004475; NM_001330170
NM_001040403; NM_001284227; NM_001284228; NM_008028; NM_001362625;
	NM_001362626; NM_001362627
	NP_001317099; NP_004466
NP_001035493; NP_001271156; NP_001271157; NP_032054; NP_001349554;
	NP_001349555; NP_001349556
	Wikidata
View/Edit Human	View/Edit Mouse

Flotillin-2 is a protein that in humans is encoded by the FLOT2 gene.^[5]^[6] Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 binds to PAR-1, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may influence tumour progression.^[7]

PDBOrtholog search: PDBe RCSB

AliasesFLOT2, ECS-1, ECS1, ESA, ESA1, M17S1, flotillin 2

External IDsOMIM: 131560; MGI: 103309; HomoloGene: 3293; GeneCards: FLOT2; OMA:FLOT2 - orthologs

Chr.Chromosome 17 (human)^[1]

Quick facts Available structures, PDB ...

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Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling.^[6]

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[7]

[1]

[2]

[3]

[4]

FLOT2

References

Further reading

Related Articles

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