FOSL2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.[5]

AliasesFOSL2, Fos-Related Antigen, FRA-2, FRA2, FOS like 2, AP-1 transcription factor subunit
End28,417,317 bp[1]
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FOSL2
Identifiers
AliasesFOSL2, Fos-Related Antigen, FRA-2, FRA2, FOS like 2, AP-1 transcription factor subunit
External IDsOMIM: 601575; MGI: 102858; HomoloGene: 3845; GeneCards: FOSL2; OMA:FOSL2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005253

NM_008037

RefSeq (protein)

NP_005244

NP_032063

Location (UCSC)Chr 2: 28.39 – 28.42 MbChr 5: 32.29 – 32.32 Mb
PubMed search[3][4]
Wikidata
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Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[5]

See also

References

Further reading

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