FREM2

FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.^[5][6]

AliasesFREM2, FRAS1 related extracellular matrix protein 2, FRASRS2, FRAS1 related extracellular matrix 2, CRYPTOP

External IDsOMIM: 608945; MGI: 2444465; HomoloGene: 18454; GeneCards: FREM2; OMA:FREM2 - orthologs

Chr.Chromosome 13 (human)^[1]

End38,887,131 bp^[1]

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FREM2
Identifiers
Aliases	FREM2, FRAS1 related extracellular matrix protein 2, FRASRS2, FRAS1 related extracellular matrix 2, CRYPTOP
External IDs	OMIM: 608945; MGI: 2444465; HomoloGene: 18454; GeneCards: FREM2; OMA:FREM2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q13.3 Start 38,687,077 bp[1] End 38,887,131 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 C|3 25.24 cM Start 53,421,359 bp[2] End 53,564,776 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla tibialis anterior muscle deltoid muscle pancreatic epithelial cell metanephros lower lobe of lung vastus lateralis muscle endometrium human kidney Skeletal muscle tissue of rectus abdominis Top expressed in molar vestibular membrane of cochlear duct epithelium of lens genital tubercle hand primitive streak migratory enteric neural crest cell vas deferens corneal epithelium tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding Cellular component plasma membrane membrane basement membrane integral component of membrane extracellular exosome Biological process multicellular organism development morphogenesis of an epithelium inner ear development development of the heart cell communication cell adhesion eye development embryonic digit morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 341640 242022 Ensembl ENSG00000150893 ENSMUSG00000037016 UniProt Q5SZK8 Q6NVD0 RefSeq (mRNA) NM_207361 NM_172862 RefSeq (protein) NP_997244 NP_766450 Location (UCSC) Chr 13: 38.69 – 38.89 Mb Chr 3: 53.42 – 53.56 Mb PubMed search [3] [4]
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This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.^[6]