Face of the giant panda sign
Medical condition
From Wikipedia, the free encyclopedia
The face of the giant panda sign, panda sign of the midbrain or double-panda sign is a characteristic "panda's face" appearance in magnetic resonance imaging (MRI) images of people with Wilson's disease. Along with Kayser–Fleischer rings, the sign is helpful in diagnosis.[1]
Complicationschoreoathetosis
Differential diagnosisWilson's disease, Wernicke's encephalopathy, Leigh syndrome, acute disseminated encephalomyelitis, toxic leukoencephalopathy, rabies
Medicationpenicillamine, thiamine, corticosteroids
| Face of the giant panda sign | |
|---|---|
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| Axial T2-weighted MRI of the brain at the level of the midbrain showing the characteristic ‘face of the giant panda’ sign, with normal red nuclei and substantia nigra (pars reticulata) against a background of hyperintensity in the tegmentum, as well as hypointensity of the superior colliculi | |
| Complications | choreoathetosis |
| Differential diagnosis | Wilson's disease, Wernicke's encephalopathy, Leigh syndrome, acute disseminated encephalomyelitis, toxic leukoencephalopathy, rabies |
| Medication | penicillamine, thiamine, corticosteroids |
While the sign is most common in Wilson's disease, it has been rarely reported in acute disseminated encephalomyelitis,[2] rabies encephalopathy,[3] toxic leukoencephalopathy[4] and Leigh syndrome.[5]
