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Famiraprinium

Selective GABAA receptor antagonist From Wikipedia, the free encyclopedia

Famiraprinium (also known as SR-95103) is a GABAA receptor antagonist used in scientific research.[1]

Quick facts Names, Identifiers ...
Famiraprinium
Names
IUPAC name
4-(6-Imino-5-methyl-3-phenylpyridazin-1-yl)butanoic acid
Other names
SR-95103
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
  • InChI=1S/C15H17N3O2/c1-11-10-13(12-6-3-2-4-7-12)17-18(15(11)16)9-5-8-14(19)20/h2-4,6-7,10,16H,5,8-9H2,1H3,(H,19,20)
    Key: LLZVAIDABZBAGE-UHFFFAOYSA-N
  • HCl: InChI=1S/C15H17N3O2.ClH/c1-11-10-13(12-6-3-2-4-7-12)17-18(15(11)16)9-5-8-14(19)20;/h2-4,6-7,10,16H,5,8-9H2,1H3,(H,19,20);1H
    Key: MDCYBLVSLOPFAZ-UHFFFAOYSA-N
  • CC1=CC(=NN(C1=N)CCCC(=O)O)C2=CC=CC=C2
  • HCl: CC1=CC(=NN(C1=N)CCCC(=O)O)C2=CC=CC=C2.Cl
Properties
C15H17N3O2
Molar mass 271.320 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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It antagonizes certain GABAA receptors with an inhibition constant of 2.2 μM.[2]

Effects

Like other GABA antagonists, it triggers epilepsy-like symptoms. These effects can be antagonized by GABAA agonists like muscimol, proving it is an antagonist.[3]

References

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