Fellutamide
Group of chemical compounds from fungi
From Wikipedia, the free encyclopedia
Fellutamides are tripeptide derivatives from Penicillium fellutanum and other fungi. They are potent proteasome inhibitor that stimulates nerve growth factor synthesis in vitro.[1][2]
Fellutamide A
Fellutamide B
Fellutamides A and F were first isolated from Aspergillus versicolor.[3][4] Fellutamides C and D were first isolated from an undescribed Metulocladosporiella (Chaetothyriales).[5]
Fellutamide B strongly inhibits the growth of the tuberculosis-causing bacterium Mycobacterium tuberculosis.[6] Its biosynthetic pathway has been determined in the filamentous fungus Aspergillus nidulans.[7]
