Van den Hende played professionally in several European cities before she moved to the United States in 1890,[4] and to New York in 1892. By 1896, an American magazine declared that "Madam Flavie Van den Hende has had a singularly successful season. Her charming personality has made her a welcome guest at most of the fashionable musicales of the season."[5]
Van den Hende was a guest soloist with the New York Symphony Orchestra, the Cincinnati Symphony Orchestra, the Chicago Symphony Orchestra, and the Metropolitan Opera.[6][7] She was a member of the New York Ladies' Trio with violinist Dora Valesca Becker and various pianists between 1895 and 1900,[8][9] violinist Ida Branth and pianist Hilda Newman in 1900,[10] and with Rossi Gisch and Hilda Newman after 1900.[1] In 1901 she joined a quartet.[11]
Van den Hende toured in the central and southern United States in 1900.[12] She toured in the South again in 1908.[13][14] In 1922, she was a member of the Verdi Club Trio with Rosalie Heller Klein and Mozelle Bennett.[1]