Fluocortin butyl

Fluocortin butyl (brand names Lenen, Novoderm, Varlane, Vaspit), or fluocortin 21-butylate, is a synthetic glucocorticoid corticosteroid which is marketed in Germany, Belgium, Luxembourg, Spain, and Italy.^[1][2] Chemically, it is the butyl ester derivative of fluocortin.^[1][2]

Trade namesLenen, Novoderm, Varlane, Vaspit

Other namesFCB; SHK-203; Fluocortin 21-butylate; Fluocortin butylate; Fluocortolone-21-carboxylate 21-butyl; 6α-Fluoro-11β-hydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-oic acid butyl ester

Drug classCorticosteroid; Glucocorticoid

CAS Number

• 41767-29-7

Quick facts Clinical data, Trade names ...

Fluocortin butyl

Clinical data
Trade names	Lenen, Novoderm, Varlane, Vaspit
Other names	FCB; SHK-203; Fluocortin 21-butylate; Fluocortin butylate; Fluocortolone-21-carboxylate 21-butyl; 6α-Fluoro-11β-hydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-oic acid butyl ester
Drug class	Corticosteroid; Glucocorticoid
Identifiers
IUPAC name Butyl 2-[(6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoacetate
CAS Number	41767-29-7
PubChem CID	15942715
ChemSpider	13085382
UNII	6N7OA9MO7O
KEGG	D04217
CompTox Dashboard (EPA)	DTXSID60194590
ECHA InfoCard	100.050.476
Chemical and physical data
Formula	C26H35FO5
Molar mass	446.559 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCOC(=O)C(=O)[C@H]1[C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2C[C@@H](C4=CC(=O)C=C[C@]34C)F)O)C)C
InChI InChI=1S/C26H35FO5/c1-5-6-9-32-24(31)23(30)21-14(2)10-17-16-12-19(27)18-11-15(28)7-8-25(18,3)22(16)20(29)13-26(17,21)4/h7-8,11,14,16-17,19-22,29H,5-6,9-10,12-13H2,1-4H3/t14-,16+,17+,19+,20+,21-,22-,25+,26+/m1/s1 Key:XWTIDFOGTCVGQB-FHIVUSPVSA-N

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It was patented in 1971 and approved for medical use in 1977.^[3]