Fluorothymidine (18F)

Fluorothymidine F-18 (FLT) is a tumor-specific PET tracer and radiopharmaceutical. It is an isotopologue of alovudine. FLT is suitable for monitoring how tumors respond to cytostatic therapy. FLT accumulates in proliferating cells where it indicates the activity of the enzyme thymidine kinase. Cell division can be characterized by the activity of that enzyme. FLT is phosphorylated as though it were thymidine, and is subsequently incorporated into DNA. Thymidine is essential for DNA replication. Considering that FLT lacks a 3′-hydroxy group, transcription of DNA is impeded following incorporating of FLT. FLT indicates changes in tumor cell proliferation by tracking the restoration of nucleosides from degenerated DNA.^[1]

Other names[18F]Fluorothymidine; ¹⁸F-3'-Fluoro-3'-deoxythymidine; ¹⁸F-FLT; ¹⁸F-alovudine

CAS Number

• 287114-80-1 ^Y

PubChem CID

• 9878109

DrugBank

• DB14930

Quick facts Clinical data, Other names ...

Fluorothymidine (¹⁸F)

Clinical data
Other names	[18F]Fluorothymidine; 18F-3'-Fluoro-3'-deoxythymidine; 18F-FLT; 18F-alovudine
Identifiers
CAS Number	287114-80-1 Y
PubChem CID	9878109
DrugBank	DB14930
ChemSpider	8053786
UNII	2X1K91UT6N
ChEMBL	ChEMBL5314940
CompTox Dashboard (EPA)	DTXSID90182869
Chemical and physical data
Formula	C10H13FN2O4
Molar mass	244.222 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C/1NC(=O)N(\C=C\1C)[C@@H]2O[C@@H]([C@@H]([18F])C2)CO
InChI InChI=1S/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s1/i11-1 Key:UXCAQJAQSWSNPQ-ZIVQXEJRSA-N

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