Del Bene began his career as a trainee under Avv. Antonio del Bene in Lecce, before becoming an Associate at the Law Firm of the Grand Officer Avv. Franco Musco. From 1994 to 1998 he worked at the offices of Professor Avv. Giulio Prosperetti & Associati in Rome, becoming a Partner. In 2005, Del Bene joined Pirola Pennuto Zei & Associati in Milan.[1]
Del Bene was a partner with Bevilacqua Lener & Partners until 2011, when he cofounded the law firm Del Bene De Vitis with fellow partner Salvatore De Vitis. The firm started with three offices located in Rome, Lecce, and Milan.[3] In 2019 he then co-founded the AVOCOM Law Firm LLP, headquartered in London, UK.[2]
In addition to his work as a law firm partner, Francesco del Bene acted as Legal Adviser to the VI Finance and Treasury Permanent Committee of the Italian Senate; collaborated with LUISS-Guido Carli and CERADI;[2] and was the Scientific Director for several scholarly journals such as the Collana di Studi Giuridici published by Key Editore in Italy[1] and Giurisprudenza di Merito, published by Giuffrè.[1]
He has also served as a professor at the University of Cassino, the University of Insubria,[2] Helsinki School of Economics and Business Law,[1] the Scuola Superiore Sant'Anna in Pisa, and is the Lead Faculty Full Professor at Blackwell Global University in Florida.[4] As a lawyer he has worked on international corporate partnerships, in which he has advocated for careful contract construction during financial dealings, in order to avoid clauses that can result in unintended losses.[5]