Frankie E. Harris taught school in Virginia after college. She became a school principal in Knoxville, Tennessee in 1871. In 1874 she accepted a position as teacher in Mississippi, but only stayed a year. After she married, Frankie E. Harris Wassom taught and wrote poetry for newspapers in Goldsboro, North Carolina.
She taught aspiring teachers at the Goldsboro Normal School[3] and was an officer of the Colored Teachers Council of Wayne County.[4] By 1893 she was teaching in Knoxville again.[1] In 1907, she was teaching at the Lincoln Institute in Kansas.[5] In 1916, she was a school principal in Odessa, Missouri.[6] In all, she taught for 54 years, including two faculty positions at black colleges.[7]
In 1886 her first book of poems was published. She showed some of her art at the North Carolina State Colored Industrial Fair that same year, and a song she wrote, "Coming to the Fair", was performed at the fair's educational convention.[1][8]