Free fraction
Pharmacokinetics parameter
From Wikipedia, the free encyclopedia
The free fraction is a parameter in pharmacokinetics and receptor-ligand kinetics. One speaks of two different free fractions:
- Plasma free fraction, previously referred to as ƒ1,[1] is now referred to as ƒP according to consensus nomenclature.[2]
- Tissue free fraction (ƒND), previously referred to as ƒ2[1]
The plasma free fraction is the fraction of the ligand at equilibrium in blood plasma that is not bound to plasma proteins.
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