GABA transaminase inhibitor
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A GABA transaminase inhibitor is a drug that acts as an inhibitor of the enzyme GABA transaminase (GABA-T), which metabolizes the major inhibitory neurotransmitter γ-aminobutyric acid (GABA).[2][4] Inhibition of GABA-T reduces the degradation of GABA, leading to increased neuronal GABA concentrations.[2] Examples of GABA-T inhibitors include valproic acid,[5] vigabatrin,[6][7] phenylethylidenehydrazine (PEH) (a metabolite of phenelzine),[8] ethanolamine-O-sulfate (EOS), and L-cycloserine, among others.[9] Certain GABA-T inhibitors, like vigabatrin, are used clinically as anticonvulsants.[2][3]
SynonymsGABA-T inhibitor; GABA metabolism inhibitor; GABA degradation inhibitor
UseEpilepsy
Biological targetGABA transaminase (GABA-T)
| GABA transaminase inhibitor | |
|---|---|
| Drug class | |
Vigabatrin (Sabril; γ-vinyl-GABA), a selective and irreversible GABA-T inhibitor used as an anticonvulsant.[1][2][3] | |
| Class identifiers | |
| Synonyms | GABA-T inhibitor; GABA metabolism inhibitor; GABA degradation inhibitor |
| Use | Epilepsy |
| Mechanism of action | GABA transaminase inhibition |
| Biological target | GABA transaminase (GABA-T) |
| Chemical class | GABA analogues and others |
| Legal status | |
| In Wikidata | |