GABRA6

Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene.^[5][6]

AliasesGABRA6, gamma-aminobutyric acid type A receptor alpha6 subunit, gamma-aminobutyric acid type A receptor subunit alpha6

External IDsOMIM: 137143; MGI: 95618; HomoloGene: 20220; GeneCards: GABRA6; OMA:GABRA6 - orthologs

Chr.Chromosome 5 (human)^[1]

End161,702,593 bp^[1]

Quick facts Identifiers, Aliases ...

GABRA6
Identifiers
Aliases	GABRA6, gamma-aminobutyric acid type A receptor alpha6 subunit, gamma-aminobutyric acid type A receptor subunit alpha6
External IDs	OMIM: 137143; MGI: 95618; HomoloGene: 20220; GeneCards: GABRA6; OMA:GABRA6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q34 Start 161,547,063 bp[1] End 161,702,593 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A5|11 25.03 cM Start 42,306,437 bp[2] End 42,321,072 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis cerebellar hemisphere right hemisphere of cerebellum paraflocculus of cerebellum pons testicle prefrontal cortex right frontal lobe Brodmann area 9 cingulate gyrus Top expressed in lobe of cerebellum cerebellar vermis deep cerebellar nuclei Epithelium of choroid plexus vestibular membrane of cochlear duct choroid plexus of fourth ventricle inferior colliculi muscle of thigh medulla oblongata cochlea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GABA-A receptor activity ion channel activity benzodiazepine receptor activity chloride channel activity extracellular ligand-gated ion channel activity transmembrane signaling receptor activity inhibitory extracellular ligand-gated ion channel activity GABA-gated chloride ion channel activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane GABA-A receptor complex postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane chloride channel complex cell junction dendrite membrane neuron projection postsynapse cerebellar Golgi cell to granule cell synapse Biological process gamma-aminobutyric acid signaling pathway chloride transmembrane transport ion transport chloride transport signal transduction ion transmembrane transport chemical synaptic transmission regulation of membrane potential nervous system process synaptic transmission, GABAergic regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2559 14399 Ensembl ENSG00000145863 ENSMUSG00000020428 UniProt Q16445 P16305 RefSeq (mRNA) NM_000811 NM_001099641 NM_008068 NM_001359049 RefSeq (protein) NP_000802 NP_001093111 NP_032094 NP_001345978 Location (UCSC) Chr 5: 161.55 – 161.7 Mb Chr 11: 42.31 – 42.32 Mb PubMed search [3] [4]
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GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.^[6]

One study found a genetic variant in the gene to be associated with the personality trait neuroticism.^[7]