GABRB1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Gamma-aminobutyric acid receptor subunit beta-1 is a protein that in humans is encoded by the GABRB1 gene.[5]
AliasesGABRB1, gamma-aminobutyric acid type A receptor beta1 subunit, EIEE45, gamma-aminobutyric acid type A receptor subunit beta1, DEE45
External IDsOMIM: 137190; MGI: 95619; HomoloGene: 20221; GeneCards: GABRB1; OMA:GABRB1 - orthologs
Function
The gamma-aminobutyric acid A receptor (GABAA receptor) is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABAA receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.[5]
Clinical significance
Mice bearing mutant copies of this gene have been shown to be vulnerable to binge drinking of alcohol.[6]
