GAPDHS

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.^[6]

In melanocytic cells GAPDHS gene expression may be regulated by MITF.^[7]

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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Glycolysis and Gluconeogenesis edit

1. [1]

   The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".