GBAS (gene)

AliasesNIPSNAP2, GBAS, glioblastoma amplified sequence, nipsnap homolog 2

External IDsOMIM: 603004; MGI: 1278343; HomoloGene: 1137; GeneCards: NIPSNAP2; OMA:NIPSNAP2 - orthologs

Chr.Chromosome 7 (human)^[1]

End56,000,181 bp^[1]

NIPSNAP2
Identifiers
Aliases	NIPSNAP2, GBAS, glioblastoma amplified sequence, nipsnap homolog 2
External IDs	OMIM: 603004; MGI: 1278343; HomoloGene: 1137; GeneCards: NIPSNAP2; OMA:NIPSNAP2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p11.2 Start 55,951,793 bp[1] End 56,000,181 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G1.3 Start 129,802,127 bp[2] End 129,835,391 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii Skeletal muscle tissue of biceps brachii vastus lateralis muscle right ventricle Skeletal muscle tissue of rectus abdominis thoracic diaphragm gastrocnemius muscle deltoid muscle muscle of thigh triceps brachii muscle Top expressed in cardiac muscle tissue of left ventricle muscle of thigh choroid plexus of fourth ventricle aortic valve atrioventricular valve skeletal muscle tissue plantaris muscle lip superior surface of tongue interventricular septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of plasma membrane membrane mitochondrion cytoplasm mitochondrial outer membrane Biological process oxidative phosphorylation negative regulation of ATP citrate synthase activity ATP biosynthetic process positive regulation of high voltage-gated calcium channel activity mitochondrion organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2631 14467 Ensembl ENSG00000146729 ENSMUSG00000029432 UniProt O75323 O55126 RefSeq (mRNA) NM_001483 NM_001202469 NM_008095 RefSeq (protein) NP_001189398 NP_001474 n/a Location (UCSC) Chr 7: 55.95 – 56 Mb Chr 5: 129.8 – 129.84 Mb PubMed search [3] [4]
Wikidata
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Protein NipSnap homolog 2 is a protein that in humans is encoded by the GBAS gene.^[5][6][7]

Chromosomal region 7p12, which contains GBAS, is amplified in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumor. The predicted 286-amino acid protein contains a signal peptide, a transmembrane domain, and 2 tyrosine phosphorylation sites. The GBAS transcript is expressed most abundantly in heart and skeletal muscle. GBAS protein might be involved in vesicular transport.^[7]