GCC2

GRIP and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the GCC2 gene.^[4][5]

PDBOrtholog search: PDBe RCSB

AliasesGCC2, GCC185, RANBP2L4, REN53, GRIP and coiled-coil domain containing 2

External IDsOMIM: 612711; MGI: 1917547; HomoloGene: 45639; GeneCards: GCC2; OMA:GCC2 - orthologs

Chr.Chromosome 2 (human)^[1]

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GCC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BBP
Identifiers
Aliases	GCC2, GCC185, RANBP2L4, REN53, GRIP and coiled-coil domain containing 2
External IDs	OMIM: 612711; MGI: 1917547; HomoloGene: 45639; GeneCards: GCC2; OMA:GCC2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.3 Start 108,449,107 bp[1] End 108,509,415 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus epididymis testicle epithelium of colon bronchial epithelial cell jejunal mucosa Epithelium of choroid plexus caput epididymis Brodmann area 23 endothelial cell n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding Cellular component cytoplasm trans-Golgi network Golgi apparatus membrane cytosol nucleoplasm Biological process Golgi to plasma membrane protein transport protein transport microtubule anchoring protein targeting to lysosome retrograde transport, endosome to Golgi late endosome to Golgi transport regulation of protein exit from endoplasmic reticulum microtubule organizing center organization recycling endosome to Golgi transport Golgi ribbon formation protein localization to Golgi apparatus transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9648 70297 Ensembl ENSG00000135968 ENSMUSG00000038039 UniProt Q8IWJ2 Q8CHG3 RefSeq (mRNA) NM_181453 NM_027375 RefSeq (protein) NP_852118 n/a Location (UCSC) Chr 2: 108.45 – 108.51 Mb n/a PubMed search [2] [3]
Wikidata
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The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[5]