GCHFR

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

GTP cyclohydrolase 1 feedback regulatory protein is an enzyme that in humans is encoded by the GCHFR gene.[5][6][7]

AliasesGCHFR, GFRP, HsT16933, P35, GTP cyclohydrolase I feedback regulator
End40,767,708 bp[1]
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GCHFR
Identifiers
AliasesGCHFR, GFRP, HsT16933, P35, GTP cyclohydrolase I feedback regulator
External IDsOMIM: 602437; MGI: 2443977; HomoloGene: 3849; GeneCards: GCHFR; OMA:GCHFR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005258

NM_177157

RefSeq (protein)

NP_005249

NP_796131

Location (UCSC)Chr 15: 40.76 – 40.77 MbChr 2: 119 – 119 Mb
PubMed search[3][4]
Wikidata
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GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.[7]

References

Further reading

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