GCM1

Chorion-specific transcription factor GCMa is a protein that, in humans, is encoded by the GCM1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesGCM1, GCMA, hGCMa, glial cells missing homolog 1, glial cells missing transcription factor 1

External IDsOMIM: 603715; MGI: 108045; HomoloGene: 2702; GeneCards: GCM1; OMA:GCM1 - orthologs

Chr.Chromosome 6 (human)^[1]

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GCM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ODH
Identifiers
Aliases	GCM1, GCMA, hGCMa, glial cells missing homolog 1, glial cells missing transcription factor 1
External IDs	OMIM: 603715; MGI: 108045; HomoloGene: 2702; GeneCards: GCM1; OMA:GCM1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.1 Start 53,126,961 bp[1] End 53,148,841 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E1|9 43.49 cM Start 77,959,206 bp[2] End 77,972,906 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta decidua testicle sperm blood kidney tubule human kidney islet of Langerhans white blood cell metanephros Top expressed in syncytiotrophoblast embryo proximal tubule right kidney yolk sac trophoblast giant cell lumbar spinal ganglion human kidney metanephros More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity zinc ion binding DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding histone deacetylase binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus Biological process regulation of transcription, DNA-templated anatomical structure morphogenesis positive regulation of syncytium formation by plasma membrane fusion transcription by RNA polymerase II transcription, DNA-templated multicellular organism development branching involved in labyrinthine layer morphogenesis astrocyte fate commitment positive regulation of transcription by RNA polymerase II gliogenesis regulation of cell differentiation involved in embryonic placenta development cell differentiation involved in embryonic placenta development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8521 14531 Ensembl ENSG00000137270 ENSMUSG00000023333 UniProt Q9NP62 P70348 RefSeq (mRNA) NM_003643 NM_008103 RefSeq (protein) NP_003634 NP_032129 Location (UCSC) Chr 6: 53.13 – 53.15 Mb Chr 9: 77.96 – 77.97 Mb PubMed search [3] [4]
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This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.^[6]

In cancer patients, GCM1 expression has been linked to both higher and lower survival rates, depending on cancer type.^[7]