GCM2

Chorion-specific transcription factor GCMb is a protein that in humans is encoded by the GCM2 gene.^[5][6]

AliasesGCM2, GCMB, hGCMb, glial cells missing homolog 2, HRPT4, glial cells missing transcription factor 2, FIH2

External IDsOMIM: 603716; MGI: 1861438; HomoloGene: 3490; GeneCards: GCM2; OMA:GCM2 - orthologs

Chr.Chromosome 6 (human)^[1]

End10,882,041 bp^[1]

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GCM2
Identifiers
Aliases	GCM2, GCMB, hGCMb, glial cells missing homolog 2, HRPT4, glial cells missing transcription factor 2, FIH2
External IDs	OMIM: 603716; MGI: 1861438; HomoloGene: 3490; GeneCards: GCM2; OMA:GCM2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p24.2 Start 10,873,223 bp[1] End 10,882,041 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.3 Start 41,254,903 bp[2] End 41,264,511 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle embryo sperm ganglionic eminence left testis right testis stomach body of stomach Top expressed in secondary oocyte zygote primary oocyte urethra male urethra Ileal epithelium parathyroid piriform cortex primary motor cortex inferior colliculi More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process transcription, DNA-templated parathyroid gland development cellular phosphate ion homeostasis regulation of transcription, DNA-templated cellular calcium ion homeostasis multicellular organism development gliogenesis positive regulation of transcription by RNA polymerase II cell differentiation involved in embryonic placenta development regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9247 107889 Ensembl ENSG00000124827 ENSMUSG00000021362 UniProt O75603 O09102 RefSeq (mRNA) NM_004752 NM_008104 RefSeq (protein) NP_004743 NP_032130 Location (UCSC) Chr 6: 10.87 – 10.88 Mb Chr 13: 41.25 – 41.26 Mb PubMed search [3] [4]
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The Drosophila 'glial cells missing' (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM]^[6]