GHMP kinase family
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| GHMP kinases N terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of the streptococcus pneumoniae phosphomevalonate kinase (pmk) | |||||||||
| Identifiers | |||||||||
| Symbol | GHMP_kinases_N | ||||||||
| Pfam | PF00288 | ||||||||
| Pfam clan | CL0329 | ||||||||
| InterPro | IPR006204 | ||||||||
| PROSITE | PDOC00545 | ||||||||
| SCOP2 | 1fwl / SCOPe / SUPFAM | ||||||||
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| GHMP kinases C terminal | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 pyrococcus furiosus galactokinase in complex with galactose, adp and magnesium | |||||||||
| Identifiers | |||||||||
| Symbol | GHMP_kinases_C | ||||||||
| Pfam | PF08544 | ||||||||
| InterPro | IPR013750 | ||||||||
| PROSITE | PDOC00545 | ||||||||
| SCOP2 | 1fwl / SCOPe / SUPFAM | ||||||||
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In molecular biology, the GHMP kinase family is a family of kinase enzymes. Members of this family include homoserine kinases EC 2.7.1.39, galactokinases EC 2.7.1.6, and mevalonate kinasesEC 2.7.1.36. These kinases make up the GHMP kinase superfamily of ATP-dependent enzymes.[1] These enzymes are involved in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. These enzymes contain, in their N-terminal section, a conserved Gly/Ser-rich region which is probably involved in the binding of ATP.[2][3] The C-terminal domain of homoserine kinase has a central alpha-beta plait fold and an insertion of four helices, which, together with the N-terminal fold, creates a novel nucleotide binding fold.[4]