GLTSCR2

Glioma tumor suppressor candidate region gene 2 protein is a protein that in humans is encoded by the GLTSCR2 gene.^[5][6][7][8]

AliasesNOP53, PICT-1, PICT1, GLTSCR2, glioma tumor suppressor candidate region gene 2, NOP53 ribosome biogenesis factor

External IDsOMIM: 605691; MGI: 2154441; HomoloGene: 44130; GeneCards: NOP53; OMA:NOP53 - orthologs

Chr.Chromosome 19 (human)^[1]

End47,757,058 bp^[1]

Quick facts NOP53, Identifiers ...

NOP53
Identifiers
Aliases	NOP53, PICT-1, PICT1, GLTSCR2, glioma tumor suppressor candidate region gene 2, NOP53 ribosome biogenesis factor
External IDs	OMIM: 605691; MGI: 2154441; HomoloGene: 44130; GeneCards: NOP53; OMA:NOP53 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 47,745,546 bp[1] End 47,757,058 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 8.64 cM|7 A2 Start 15,670,108 bp[2] End 15,679,999 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary body of pancreas right ovary skin of arm skin of leg ganglionic eminence skin of abdomen canal of the cervix body of uterus right uterine tube Top expressed in neural layer of retina ventricular zone yolk sac lip transitional epithelium of urinary bladder muscle of thigh esophagus genital tubercle molar granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding 5S rRNA binding protein binding p53 binding identical protein binding Cellular component intracellular anatomical structure intracellular membrane-bounded organelle nucleus nucleolus cytosol fibrillar center rDNA heterochromatin nucleoplasm Biological process ribosomal large subunit assembly regulation of protein phosphorylation protein stabilization regulation of signal transduction by p53 class mediator negative regulation of signal transduction by p53 class mediator regulation of aerobic respiration ribosomal large subunit export from nucleus negative regulation of transcription by RNA polymerase II DNA repair mitotic G2 DNA damage checkpoint signaling negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of protein-containing complex assembly negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of apoptotic process regulation of cell cycle cellular response to hypoxia protein localization to nucleolus protein localization to nucleoplasm cellular response to DNA damage stimulus regulation of RIG-I signaling pathway negative regulation of protein kinase B signaling negative regulation of transcription of nucleolar large rRNA by RNA polymerase I positive regulation of protein K63-linked deubiquitination ribosome biogenesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29997 68077 Ensembl ENSG00000105373 ENSMUSG00000041560 UniProt Q9NZM5 Q8BK35 RefSeq (mRNA) NM_015710 NM_133831 RefSeq (protein) NP_056525 NP_598592 Location (UCSC) Chr 19: 47.75 – 47.76 Mb Chr 7: 15.67 – 15.68 Mb PubMed search [3] [4]
Wikidata
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