NOP53

NOP53
Identifiers
Aliases	NOP53, PICT-1, PICT1, GLTSCR2, glioma tumor suppressor candidate region gene 2, NOP53 ribosome biogenesis factor
External IDs	OMIM: 605691; MGI: 2154441; GeneCards: NOP53
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,757,058 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	15,679,999 bp
RNA expression pattern
	Top expressed in
	left ovary; ; body of pancreas; ; right ovary; ; skin of arm; ; skin of leg; ; ganglionic eminence; ; skin of abdomen; ; canal of the cervix; ; body of uterus; ; right uterine tube;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; yolk sac; ; lip; ; transitional epithelium of urinary bladder; ; muscle of thigh; ; esophagus; ; genital tubercle; ; molar; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA binding; 5S rRNA binding; protein binding; p53 binding; identical protein binding;
Cellular component	intracellular anatomical structure; intracellular membrane-bounded organelle; nucleus; nucleolus; cytosol; fibrillar center; rDNA heterochromatin; nucleoplasm;
Biological process	ribosomal large subunit assembly; regulation of protein phosphorylation; protein stabilization; regulation of signal transduction by p53 class mediator; negative regulation of signal transduction by p53 class mediator; regulation of aerobic respiration; ribosomal large subunit export from nucleus; negative regulation of transcription by RNA polymerase II; DNA repair; mitotic G2 DNA damage checkpoint signaling; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein-containing complex assembly; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of apoptotic process; regulation of cell cycle; cellular response to hypoxia; protein localization to nucleolus; protein localization to nucleoplasm; cellular response to DNA damage stimulus; regulation of RIG-I signaling pathway; negative regulation of protein kinase B signaling; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I; positive regulation of protein K63-linked deubiquitination; ribosome biogenesis; rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	29997
	68077
	ENSG00000105373
	ENSMUSG00000041560
	Q9NZM5
	Q8BK35
	NM_015710
	NM_133831
	NP_056525
	NP_598592
	Wikidata
View/Edit Human	View/Edit Mouse