GMPPB

Mannose-1-phosphate guanyltransferase beta is an enzyme that in humans is encoded by the GMPPB gene.^[4]

AliasesGMPPB, MDDGA14, MDDGB14, MDDGC14, GDP-mannose pyrophosphorylase B, LGMDR19

External IDsOMIM: 615320; MGI: 2660880; GeneCards: GMPPB

Chr.Chromosome 9 (mouse)^[1]

End107,930,000 bp^[1]

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GMPPB
Identifiers
Aliases	GMPPB, MDDGA14, MDDGB14, MDDGC14, GDP-mannose pyrophosphorylase B, LGMDR19
External IDs	OMIM: 615320; MGI: 2660880; GeneCards: GMPPB
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.7.13 ↗ ↗ ↗ ↗
Gene location (Mouse) Chr. Chromosome 9 (mouse)[1] Band 9|9 F1 Start 107,926,441 bp[1] End 107,930,000 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas anterior pituitary bone marrow cell right lobe of thyroid gland minor salivary glands right lobe of liver left lobe of thyroid gland right adrenal gland left adrenal gland body of stomach Top expressed in epithelium of small intestine intestinal villus Ileal epithelium jejunum duodenum islet of Langerhans spermatid proximal tubule placenta colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity mannose-1-phosphate guanylyltransferase activity nucleotide binding nucleotidyltransferase activity GTP binding protein binding Cellular component cytoplasm Biological process biosynthesis GDP-mannose biosynthetic process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry Species Human Mouse Entrez 29925 331026 Ensembl n/a ENSMUSG00000070284 UniProt Q9Y5P6 Q8BTZ7 RefSeq (mRNA) NM_021971 NM_013334 NM_177910 NM_001357682 RefSeq (protein) NP_037466 NP_068806 NP_808578 NP_001344611 Location (UCSC) n/a Chr 9: 107.93 – 107.93 Mb PubMed search [2] [3]
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This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. The gene encodes two transcript variants.^[4]