GNAO1

Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene. This protein is part of the G_i/o family of G-proteins, which function by inhibiting adenylyl cyclase as part of G protein-coupled receptor signaling.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesGNAO1, EIEE17, G-ALPHA-o, GNAO, G protein subunit alpha o1, HLA-DQB1, NEDIM, DEE17, HG1G

External IDsOMIM: 139311; MGI: 95775; HomoloGene: 39203; GeneCards: GNAO1; OMA:GNAO1 - orthologs

Chr.Chromosome 16 (human)^[1]

Quick facts Available structures, PDB ...

GNAO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3C7K
Identifiers
Aliases	GNAO1, EIEE17, G-ALPHA-o, GNAO, G protein subunit alpha o1, HLA-DQB1, NEDIM, DEE17, HG1G
External IDs	OMIM: 139311; MGI: 95775; HomoloGene: 39203; GeneCards: GNAO1; OMA:GNAO1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q13 Start 56,191,390 bp[1] End 56,357,444 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C5|8 45.94 cM Start 94,536,594 bp[2] End 94,696,016 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superficial temporal artery entorhinal cortex superior frontal gyrus prefrontal cortex right frontal lobe putamen postcentral gyrus buccal mucosa cell caudate nucleus primary visual cortex Top expressed in perirhinal cortex entorhinal cortex CA3 field superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell habenula cerebellar cortex neural layer of retina subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding G-protein beta/gamma-subunit complex binding signal transducer activity metal ion binding guanyl nucleotide binding GTP binding GTPase activity signaling receptor binding G protein-coupled serotonin receptor binding mu-type opioid receptor binding GTPase activating protein binding protein-containing complex binding corticotropin-releasing hormone receptor 1 binding G protein-coupled receptor binding Cellular component cell body membrane myelin sheath plasma membrane dendrite heterotrimeric G-protein complex neuron projection protein-containing complex Biological process G protein-coupled receptor signaling pathway response to cytokine muscle contraction regulation of heart contraction response to organic cyclic compound locomotory behavior adenylate cyclase-modulating G protein-coupled receptor signaling pathway ageing dopamine receptor signaling pathway response to morphine positive regulation of GTPase activity response to organonitrogen compound negative regulation of calcium ion transport forebrain development neuron projection development response to hydrogen peroxide cellular process or phenomenon signal transduction protein folding Wnt signaling pathway, calcium modulating pathway odontogenesis of dentin-containing tooth Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2775 14681 Ensembl ENSG00000087258 ENSMUSG00000031748 UniProt P09471 Q8N6I9 P18872 RefSeq (mRNA) NM_020988 NM_138736 NM_001113384 NM_010308 RefSeq (protein) NP_066268 NP_620073 NP_066268.1 NP_620073.2 NP_001106855 NP_034438 Location (UCSC) Chr 16: 56.19 – 56.36 Mb Chr 8: 94.54 – 94.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

Mutations in this gene have been shown to cause epileptic encephalopathy.^[8]