GNB4

Guanine nucleotide-binding protein subunit beta-4 is a protein that in humans is encoded by the GNB4 gene.^[5][6][7]

AliasesGNB4, CMTD1F, G protein subunit beta 4, HG2B

External IDsOMIM: 610863; MGI: 104581; HomoloGene: 69140; GeneCards: GNB4; OMA:GNB4 - orthologs

Chr.Chromosome 3 (human)^[1]

End179,451,476 bp^[1]

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GNB4
Identifiers
Aliases	GNB4, CMTD1F, G protein subunit beta 4, HG2B
External IDs	OMIM: 610863; MGI: 104581; HomoloGene: 69140; GeneCards: GNB4; OMA:GNB4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.33 Start 179,396,088 bp[1] End 179,451,476 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A3 Start 32,634,481 bp[2] End 32,670,734 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm secondary oocyte skin of thigh tibia skin of hip visceral pleura parietal pleura synovial membrane saphenous vein trigeminal ganglion Top expressed in semi-lunar valve ascending aorta lumbar spinal ganglion aortic valve dermis primary oocyte vas deferens tunica media of zone of aorta superior cervical ganglion yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function protein-containing complex binding signal transducer activity Cellular component myelin sheath lysosomal membrane extracellular exosome cytosol Biological process cellular response to glucagon stimulus substantia nigra development signal transduction protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59345 14696 Ensembl ENSG00000114450 ENSMUSG00000027669 UniProt Q9HAV0 P29387 RefSeq (mRNA) NM_021629 NM_013531 NM_001348062 NM_001348104 NM_001348105 RefSeq (protein) NP_067642 NP_038559 NP_001334991 NP_001335033 NP_001335034 Location (UCSC) Chr 3: 179.4 – 179.45 Mb Chr 3: 32.63 – 32.67 Mb PubMed search [3] [4]
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Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.^[7]