GNL3

GNL3
Identifiers
Aliases	GNL3, C77032, E2IG3, NNP47, NS, G protein nucleolar 3
External IDs	OMIM: 608011; MGI: 1353651; HomoloGene: 56670; GeneCards: GNL3; OMA:GNL3 - orthologs
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,741,109 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; body of pancreas; ; islet of Langerhans; ; minor salivary glands; ; rectum; ; thymus; ; peritoneum; ; skin of abdomen; ; anterior pituitary; ; left uterine tube;
	Top expressed in
	tail of embryo; ; epiblast; ; genital tubercle; ; embryo; ; morula; ; embryo; ; ovary; ; uterus; ; blastocyst; ; placenta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; RNA binding; GTPase activity; mRNA 5'-UTR binding;
Cellular component	membrane; nucleus; nucleoplasm; nucleolus; extracellular space; nuclear body;
Biological process	positive regulation of protein localization to chromosome, telomeric region; positive regulation of telomere maintenance; cell population proliferation; regulation of cell population proliferation; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of protein sumoylation; stem cell division; stem cell population maintenance; ribosome biogenesis;
	Sources:Amigo / QuickGO
Orthologs
	26354
	30877
	n/a
	ENSMUSG00000042354
	Q9BVP2
	Q8CI11
	NM_206826; NM_014366; NM_206825
	NM_153547; NM_178846
	NP_055181; NP_996561; NP_996562
	NP_705775
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene.^[4]^[5]^[6] It is found within the nucleolus that binds p53.^[7] Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses.^[7] It is a marker for many stem cells and cancer cells.^[8]