GPAM

Glycerol-3-phosphate acyltransferase 1, mitochondrial is an enzyme that in humans is encoded by the GPAM gene.^[5][6][7]

AliasesGPAM, GPAT, GPAT1, glycerol-3-phosphate acyltransferase, mitochondrial

External IDsOMIM: 602395; MGI: 109162; HomoloGene: 7343; GeneCards: GPAM; OMA:GPAM - orthologs

Chr.Chromosome 10 (human)^[1]

End112,215,377 bp^[1]

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GPAM
Identifiers
Aliases	GPAM, GPAT, GPAT1, glycerol-3-phosphate acyltransferase, mitochondrial
External IDs	OMIM: 602395; MGI: 109162; HomoloGene: 7343; GeneCards: GPAM; OMA:GPAM - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.2 Start 112,149,865 bp[1] End 112,215,377 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 D2|19 50.81 cM Start 55,055,700 bp[2] End 55,115,670 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium corpus epididymis skin of hip liver adipose tissue subcutaneous adipose tissue vena cava synovial joint right adrenal cortex right lobe of liver Top expressed in retinal pigment epithelium ankle brown adipose tissue vastus lateralis muscle temporal muscle digastric muscle sternocleidomastoid muscle right ventricle intercostal muscle soleus muscle More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity O-acyltransferase activity acyltransferase activity glycerol-3-phosphate O-acyltransferase activity sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Cellular component integral component of membrane mitochondrion membrane mitochondrial outer membrane plasma membrane mitochondrial membranes Biological process phospholipid biosynthetic process positive regulation of activated T cell proliferation lipid metabolism glycerophospholipid metabolic process phosphatidic acid biosynthetic process metabolism negative regulation of activation-induced cell death of T cells triglyceride metabolic process acyl-CoA metabolic process fatty acid metabolic process CDP-diacylglycerol biosynthetic process fatty acid homeostasis defense response to virus positive regulation of multicellular organism growth response to glucose phospholipid homeostasis triglyceride biosynthetic process cellular lipid metabolic process regulation of cholesterol biosynthetic process regulation of intracellular estrogen receptor signaling pathway glycerol-3-phosphate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57678 14732 Ensembl ENSG00000119927 ENSMUSG00000024978 UniProt Q9HCL2 Q61586 RefSeq (mRNA) NM_001244949 NM_020918 NM_008149 NM_001356285 RefSeq (protein) NP_001231878 NP_065969 NP_032175 NP_001343214 Location (UCSC) Chr 10: 112.15 – 112.22 Mb Chr 19: 55.06 – 55.12 Mb PubMed search [3] [4]
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Glycerol-3-phosphate acyltransferase (GPAT; EC 2.3.1.15), which catalyzes the initial and committing step in glycerolipid biosynthesis, is predicted to play a pivotal role in the regulation of cellular triacylglycerol and phospholipid levels. Two mammalian forms of GPAT have been identified on the basis of localization to either the endoplasmic reticulum or mitochondria.[supplied by OMIM]^[7]