GPR114

ADGRG5
Identifiers
Aliases	ADGRG5, PGR27, GPR114, adhesion G protein-coupled receptor G5
External IDs	OMIM: 616965; MGI: 2685955; GeneCards: ADGRG5
Gene location (Human)
Chr.	Chromosome 16 (human)
End	57,591,681 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,669,908 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; blood; ; testicle; ; islet of Langerhans; ; spleen; ; bone marrow cell; ; appendix; ; epithelium of nasopharynx; ; tonsil;
	Top expressed in
	mesenteric lymph nodes; ; secondary oocyte; ; primary oocyte; ; spleen; ; embryo; ; thymus; ; jejunum; ; zygote; ; blood; ; subcutaneous adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; membrane; plasma membrane; intracellular anatomical structure; integral component of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	221188
	382045
	ENSG00000159618
	ENSMUSG00000061577
	Q8IZF4
	Q3V3Z3
	NM_001304376; NM_153837; NM_001318481
	NM_001033468; NM_001145972
	NP_001291305; NP_001305410; NP_722579
	NP_001028640; NP_001139444
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene.^[5]^[6]^[7] GPR114 is a member of the adhesion GPCR family.^[8]^[9] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[10]