GPR124
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.[5][6][7] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[8][9][10]
Interactions
GPR124 has been shown to interact with DLG1[11] and is involved in the Wnt/β-catenin signaling pathway along with RECK.[12] GPR124 is the predicted target of several Group IV (+)ssRNA neuroinvasive viruses; proteolytic cleavage of GPR124 by these viral proteases may be important for entry into the brain.[13] GPR124 (ADGRA2) was predicted using SSHHPS.
Zebrafish embryos with Gpr124 loss of function demonstrate severe angiogenic deficiencies in the central nervous system.
