GPR146

GPR146
Identifiers
Aliases	GPR146, PGR8, G protein-coupled receptor 146
External IDs	MGI: 1933113; GeneCards: GPR146
Gene location (Human)
Chr.	Chromosome 7 (human)
End	1,059,261 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	139,396,415 bp
RNA expression pattern
	Top expressed in
	subcutaneous adipose tissue; ; abdominal fat; ; apex of heart; ; gastric mucosa; ; right lung; ; tibial nerve; ; blood; ; left ventricle; ; body of stomach; ; upper lobe of left lung;
	Top expressed in
	interventricular septum; ; retinal pigment epithelium; ; muscle of thigh; ; myocardium of ventricle; ; left lobe of liver; ; right lung; ; triceps brachii muscle; ; right kidney; ; right lung lobe; ; stroma of bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	115330
	80290
	ENSG00000164849
	ENSMUSG00000044197
	Q96CH1
	Q99LE2
	NM_001303473; NM_001303474; NM_138445
	NM_001038703; NM_030258
	NP_001290402; NP_001290403; NP_612454
	NP_001033792; NP_084534; NP_001349135
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene.^[5] The receptor has been shown to bind cholesin, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption. In response to cholesin binding, GPR146 signaling inhibit cholesterol synthesis.^[6] Consistent with this interaction, murine genetic disruption of GPR146 lowers serum cholesterol and reduces atherosclerotic aortic lesions.^[7] GPR146 has also been identified as a possible receptor for C-peptide.^[8]