GPR151

GPR151
Identifiers
Aliases	GPR151, GALR4, GALRL, GPCR, PGR7, G protein-coupled receptor 151, GPCR-2037
External IDs	OMIM: 618487; MGI: 2441887; GeneCards: GPR151
Gene location (Human)
Chr.	Chromosome 5 (human)
End	146,516,190 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	42,712,717 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; C1 segment; ; Brodmann area 9; ; superior frontal gyrus; ; primary visual cortex; ; ganglionic eminence; ; anterior cingulate cortex; ; substantia nigra; ; right frontal lobe; ; putamen;
	Top expressed in
	habenula; ; lumbar spinal ganglion; ; epithelium of small intestine; ; paraventricular nucleus of thalamus; ; embryo; ; blastocyst; ; lateral habenular nucleus; ; gastrula; ; central medial nucleus; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	134391
	240239
	ENSG00000173250
	ENSMUSG00000042816
	Q8TDV0
	Q7TSN6
	NM_194251
	NM_181543
	NP_919227
	NP_853521
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 151 is a protein that in humans is encoded by the GPR151 gene.^[5]^[6] It is weakly activated by galanin, but its endogenous ligand remains unknown. Studies have suggested GPR151 may play a role in several clinically significant processes such as inflammation, pain perception and reward-seeking behavior as well as hepatic glucose production, but further research into its function has been limited so far by a lack of selective agonists and antagonists for this receptor, with most research to date using knockout mice.^[7]^[8]^[9]^[10]^[11]