GPR161

GPR161
Identifiers
Aliases	GPR161, RE2, G protein-coupled receptor 161
External IDs	OMIM: 612250; MGI: 2685054; HomoloGene: 17824; GeneCards: GPR161; OMA:GPR161 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	168,137,667 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	165,154,314 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; myometrium; ; buccal mucosa cell; ; ventricular zone; ; tail of epididymis; ; body of uterus; ; pars reticulata; ; stromal cell of endometrium; ; spinal ganglia; ; pars compacta;
	Top expressed in
	subiculum; ; otic vesicle; ; Region I of hippocampus proper; ; ganglionic eminence; ; hand; ; lumbar spinal ganglion; ; morula; ; medial ganglionic eminence; ; hippocampus proper; ; ascending aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity;
Cellular component	plasma membrane; cell projection; membrane; ciliary membrane; integral component of membrane; endocytic vesicle membrane; cilium; recycling endosome;
Biological process	multicellular organism development; signal transduction; G protein-coupled receptor signaling pathway; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23432
	240888
	ENSG00000143147
	ENSMUSG00000040836
	Q8N6U8
	B2RPY5
NM_001267609; NM_001267610; NM_001267611; NM_001267612; NM_001267613;
	NM_001267614; NM_007369; NM_153832; NM_001349632; NM_001349633; NM_001349634; NM_001349635; NM_001375883; NM_001375884; NM_001375885; NM_001381909
	NM_001081126; NM_001310429; NM_001310430
NP_001254538; NP_001254539; NP_001254540; NP_001254541; NP_001254542;
	NP_001254543; NP_722561; NP_001336561; NP_001336562; NP_001336563; NP_001336564; NP_001362812; NP_001362813; NP_001362814; NP_001368838
	NP_001074595; NP_001297358; NP_001297359
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 161 is a protein that in humans is encoded by the GPR161 gene.^[5]^[6] It is located on primary cilia and regulates embryonic development through suppression of the hedgehog signaling pathway. It appears to act as a mechanoreceptor and may not require an endogenous ligand for activation.^[7]^[8]^[9]^[10]