GUCY1B1

GUCY1B1
Identifiers
Aliases	GUCY1B1, guanylate cyclase 1, soluble, beta 3, GUCSB3, guanylate cyclase 1 soluble subunit beta, GC-SB3, GUC1B3, GC-S-beta-1, guanylate cyclase 1 soluble subunit beta 1, GUCB3, GUCY1B3
External IDs	OMIM: 139397; MGI: 1860604; GeneCards: GUCY1B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WZ1, 3UVJ, 4NI2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 4 (human)
End	155,807,811 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	81,981,996 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; orbitofrontal cortex; ; lateral nuclear group of thalamus; ; superior frontal gyrus; ; Brodmann area 46; ; postcentral gyrus; ; Brodmann area 23; ; pars compacta; ; pons; ; entorhinal cortex;
	Top expressed in
	olfactory tubercle; ; habenula; ; lateral septal nucleus; ; anterior amygdaloid area; ; globus pallidus; ; left lung lobe; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; dorsal tegmental nucleus; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; guanylate cyclase activity; GTP binding; metal ion binding; protein binding; heme binding; lyase activity; phosphorus-oxygen lyase activity; signaling receptor activity; adenylate cyclase activity;
Cellular component	plasma membrane; guanylate cyclase complex, soluble; cytoplasm; presynaptic active zone;
Biological process	intracellular signal transduction; cyclic nucleotide biosynthetic process; blood circulation; nitric oxide-cGMP-mediated signaling pathway; cGMP biosynthetic process; nitric oxide mediated signal transduction; cellular response to nitric oxide; cGMP-mediated signaling; trans-synaptic signaling by nitric oxide, modulating synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2983
	54195
	ENSG00000061918
	ENSMUSG00000028005
	Q02153
	O54865
NM_000857; NM_001291951; NM_001291952; NM_001291953; NM_001291954;
	NM_001291955
	NM_001161796; NM_017469
NP_000848; NP_001278880; NP_001278881; NP_001278882; NP_001278883;
	NP_001278884
	NP_001155268; NP_059497
	Wikidata
View/Edit Human	View/Edit Mouse

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B1 gene (previously GUCY1B3).^[5]^[6]

AliasesGUCY1B1, guanylate cyclase 1, soluble, beta 3, GUCSB3, guanylate cyclase 1 soluble subunit beta, GC-SB3, GUC1B3, GC-S-beta-1, guanylate cyclase 1 soluble subunit beta 1, GUCB3, GUCY1B3

External IDsOMIM: 139397; MGI: 1860604; GeneCards: GUCY1B1

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 4 (human)^[1]

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GUCY1B1

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