GW-1100

CAS Number

• 306974-70-9

PubChem CID

• 11692123

IUPHAR/BPS

• 1057

ChemSpider

• 9866850

GW-1100

Identifiers
IUPAC name ethyl 4-[5-[(2-ethoxypyrimidin-5-yl)methyl]-2-[(4-fluorophenyl)methylsulfanyl]-4-oxopyrimidin-1-yl]benzoate
CAS Number	306974-70-9
PubChem CID	11692123
IUPHAR/BPS	1057
ChemSpider	9866850
ChEMBL	ChEMBL4303679
CompTox Dashboard (EPA)	DTXSID80470686
Chemical and physical data
Formula	C27H25FN4O4S
Molar mass	520.58 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCOC1=NC=C(C=N1)CC2=CN(C(=NC2=O)SCC3=CC=C(C=C3)F)C4=CC=C(C=C4)C(=O)OCC
InChI InChI=1S/C27H25FN4O4S/c1-3-35-25(34)20-7-11-23(12-8-20)32-16-21(13-19-14-29-26(30-15-19)36-4-2)24(33)31-27(32)37-17-18-5-9-22(28)10-6-18/h5-12,14-16H,3-4,13,17H2,1-2H3 Key:PTPNCCWOTBBVJR-UHFFFAOYSA-N

GW-1100 (GW1100) is an experimental drug which acts as a potent and selective antagonist for the free fatty acid receptor FFAR1 (GPR40).^[1][2] Agonists for this receptor have potentially useful antiinflammatory and anti-fibrotic effects, and while GW-1100 does not have therapeutic effects in its own right, it is important for research into the FFAR1 receptor as it allows comparison testing to measure the effectiveness of FFAR1 agonists.^{[1][3][4][5][6][7][8]} GW-1100 also showed inhibition of cancer cell growth in vitro, suggesting potential applications of FFAR1 antagonists in the treatment of cancer.^[9][10]