GW9508

GW9508 is an experimental drug which acts as a mixed agonist for the free fatty acid receptors FFAR1 (GPR40) and FFAR4 (GPR120). It is around 60x more potent as an agonist at FFAR1,^[1] but has nevertheless often been used as a model agonist for FFAR4 especially in tissues which lack FFAR1 or in the presence of FFAR1 antagonists,^[2] due to a historical lack of availability of highly selective FFAR4 agonists.^[3] It has antiinflammatory effects^[4][5][6] and has also been used to study the role of FFAR1 and FFAR4 in various processes such as regulation of insulin^[7] and ghrelin^[8] release, immune system function,^[9][10] and maintenance of bone density.^[11]

CAS Number

• 885101-89-3

PubChem CID

• 11595431

IUPHAR/BPS

• 1050

ChemSpider

• 9770191

Quick facts Identifiers, CAS Number ...

GW9508

Identifiers
IUPAC name 3-[4-[(3-phenoxyphenyl)methylamino]phenyl]propanoic acid
CAS Number	885101-89-3
PubChem CID	11595431
IUPHAR/BPS	1050
ChemSpider	9770191
UNII	4T77GYP2CS
ChEBI	CHEBI:93259
ChEMBL	ChEMBL207881
CompTox Dashboard (EPA)	DTXSID70237088
ECHA InfoCard	100.161.077
Chemical and physical data
Formula	C22H21NO3
Molar mass	347.414 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
InChI InChI=1S/C22H21NO3/c24-22(25)14-11-17-9-12-19(13-10-17)23-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15,23H,11,14,16H2,(H,24,25) Key:DGENZVKCTGIDRZ-UHFFFAOYSA-N

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