GZMM

Granzyme M is a protein that in humans is encoded by the GZMM gene.^[5][6]

PDBHuman UniProt search: PDBe RCSB

AliasesGZMM, LMET1, MET1, granzyme M

External IDsOMIM: 600311; MGI: 99549; HomoloGene: 21099; GeneCards: GZMM; OMA:GZMM - orthologs

Chr.Chromosome 19 (human)^[1]

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GZMM
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2ZGC, 2ZGH, 2ZGJ, 2ZKS
Identifiers
Aliases	GZMM, LMET1, MET1, granzyme M
External IDs	OMIM: 600311; MGI: 99549; HomoloGene: 21099; GeneCards: GZMM; OMA:GZMM - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 544,034 bp[1] End 549,924 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 79,524,854 bp[2] End 79,531,095 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood spleen lymph node appendix mucosa of transverse colon thymus cerebellar hemisphere right hemisphere of cerebellum bone marrow Top expressed in neural layer of retina muscle of thigh morula retinal pigment epithelium interventricular septum olfactory epithelium embryo embryo granulocyte blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity endopeptidase activity serine-type endopeptidase activity hydrolase activity protein binding Cellular component extracellular region membrane Biological process innate immune response cell death cytolysis proteolysis immune system process apoptotic process T cell mediated cytotoxicity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3004 16904 Ensembl ENSG00000197540 ENSMUSG00000054206 UniProt P51124 n/a RefSeq (mRNA) NM_005317 NM_001258351 NM_008504 NM_001302485 NM_001302499 RefSeq (protein) NP_001245280 NP_005308 n/a Location (UCSC) Chr 19: 0.54 – 0.55 Mb Chr 10: 79.52 – 79.53 Mb PubMed search [3] [4]
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Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.^[6]