Galactose mutarotase

GALM
Identifiers
Aliases	GALM, BLOCK25, GLAT, HEL-S-63p, IBD1, galactose mutarotase (aldose 1-epimerase), galactose mutarotase, GALAC4
External IDs	OMIM: 137030; MGI: 2442420; GeneCards: GALM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SNZ, 1SO0
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	38,741,237 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	80,492,530 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; pancreatic ductal cell; ; left adrenal gland; ; left adrenal cortex; ; duodenum; ; right uterine tube; ; renal medulla; ; jejunal mucosa; ; human kidney;
	Top expressed in
	olfactory epithelium; ; lacrimal gland; ; vestibular membrane of cochlear duct; ; left lobe of liver; ; epithelium of stomach; ; jejunum; ; gallbladder; ; right kidney; ; primary oocyte; ; superior surface of tongue;
	More reference expression data
	n/a
Gene ontology
Molecular function	isomerase activity; aldose 1-epimerase activity; carbohydrate binding; catalytic activity;
Cellular component	extracellular exosome; cytoplasm;
Biological process	hexose metabolic process; glucose metabolic process; galactose metabolic process; galactose catabolic process via UDP-galactose; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	130589
	319625
	ENSG00000143891
	ENSMUSG00000035473
	Q96C23
	Q8K157
	NM_138801
	NM_176963
	NP_620156
	NP_795937
	Wikidata
View/Edit Human	View/Edit Mouse

Galactose mutarotase (aldose 1-epimerase) (gene name GALM) is a human enzyme that reversibly converts α-aldose to the β-anomer.^[5] This enzyme catalyzes the first step of the Leloir pathway, which is involved in galactose metabolism.^[6] It belongs to family of aldose epimerases.

AliasesGALM, BLOCK25, GLAT, HEL-S-63p, IBD1, galactose mutarotase (aldose 1-epimerase), galactose mutarotase, GALAC4

External IDsOMIM: 137030; MGI: 2442420; GeneCards: GALM

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 2 (human)^[1]

Quick facts GALM, Identifiers ...

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The two main amino acids in the enzyme active site are Glu 304, which acts as a Bronsted-Lowry base and removes a proton, and His 170, which acts as Bronsted-Lowry Acid and donates a proton to the galactose.^[7]

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Galactose mutarotase

References

External links

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