Griffin was signed by the New Orleans Saints as an undrafted free agent on June 6, 2016.[3] He was waived by the Saints on September 3, 2016, and was signed to the practice squad the next day.[4][5] After spending the entire season on the practice squad, Griffin signed a reserve/future contract with the Saints on January 2, 2017.[6]
On September 2, 2017, Griffin was waived by the Saints and was signed to the practice squad the next day.[7][8] He was promoted to the active roster on December 2, 2017.[9] He appeared in three games during December, making one catch for four yards.[10] He was placed on injured reserve on January 3, 2018, with a foot injury.[11]
On September 1, 2018, Griffin was waived by the Saints and was signed to the practice squad the next day.[12][13] He was promoted to the active roster on January 12, 2019.[14] Eight days later, he had his first career touchdown reception in the NFC Championship Game against the Los Angeles Rams.[15]
Griffin was placed on injured reserve on August 26, 2019, with an ankle injury.[16]
On September 5, 2020, Griffin waived by the Saints and signed to the practice squad the next day.[17][18] He was elevated to the active roster on October 3 and October 12 for the team's weeks 4 and 5 games against the Detroit Lions and Los Angeles Chargers, and reverted to the practice squad after each game.[19][20] He was signed to the active roster on November 21, 2020.[21] On December 19, 2020, the Saints waived Griffin[22] and re-signed him to their practice squad three days later.[23] He was elevated again on January 2, 2021, for the week 17 game against the Carolina Panthers, and reverted to the practice squad again following the game.[24] On January 18, 2021, Griffin signed a reserve/futures contract with the Saints.[25]
On December 18, 2021, Griffin was placed on injured reserve.
On March 28, 2022, Griffin signed with the Detroit Lions.[26] He was released on August 15, 2022.[27] He was re-signed to the practice squad on August 31.[28]