On 20 October 2008, Williams was shot, at close range, while walking on a quiet street in Kabul.[2]
Douglas Alexander, UK Secretary of State for International Development, condemned the murder: "Her killing was a callous and cowardly act by people who would take Afghanistan back to the dark days of the Taliban tyranny which scarred the country for so long."[2]
Mike Lythe, head of Serve Afghanistan, said, "This is a tragedy... She knew the dangers, but Afghanistan is where she wanted to be."[2] Following the killing, the organisation suspended its work in the country. The Foreign Office also updated its advice for people travelling to the country, stating that no part should be "considered immune from violence".[5]
The London-based scholar Ziauddin Sardar described the killing as "another barbaric act in the name of Islam" and called on all Muslims to condemn the Taliban.[6]
Following Williams' funeral, her mother and sister met President Hamid Karzai who wished to express his condolences.[4] Her sister Karen Williams stated that they had forgiven the killers as Gayle would have done.[5]
The family arranged a memorial service in London the week after. They asked for no flowers but for donations to be sent for the welfare of deprived Afghan children.[3]
Responding to the murder of Gayle Williams, there were calls for Christians to end evangelism. However, a worldwide commission of evangelical Christian theologians, meeting in Bangkok on 23–25 October, reaffirmed the importance of holistic mission.[7]
A "prayer walk" for Williams' family and colleagues was arranged for 8 November 2008 in London, stopping to pray outside embassies of countries where Christian believers face persecution.[8]
The Centre for Safety and Development, which gives training to avoid attacks on humanitarian workers, notes that Williams trustfully walked the same route to work each day, and advises workers with NGOs to take more precautions.[9]