George Mercer surveyed lands on the frontier, including across the Appalachian Mountains which the Virginia colony claimed according to its charter (which like that of Pennsylvania set no western boundary, unlike that issued to Maryland), particularly those in which his father or the Ohio Company (in which his father and many other Tidewater planters, including George Washington invested) were interested in developing. Native Americans often disagreed with the colonial claims. Thus, frontier settlements were subject to attack, particularly since France also claimed much of North America and French and British traders sold weapons in exchange for furs either at trading posts or during their journeys further into the frontier. The Ohio Company had established one fortified trading post and storehouse at Ridgeley in western Virginia not far across the Potomac River headwaters from Cumberland, Maryland in 1750.
In 1754, as the French and Indian War began, Mercer joined the provincial Virginia Regiment as a lieutenant. He served under Captain (later Colonel) George Washington, a fellow surveyor raised in Stafford County near Fredericksburg. Later that year, he would be wounded in defending Fort Necessity,[5] and be promoted to captain. The Virginia General Assembly had placed Washington in charge of the frontier's defense, and he took over existing frontier forts and created others (that at Ridgeley became "Fort Ohio"). Washington would name his base Fort Loudoun (which defended Winchester, the seat of then-vast Frederick County).[6] Lt. John Fenton Mercer, George's slightly younger brother, was killed and scalped at Edwards's Fort in April 1756.[7][8] In 1758, George Mercer accepted command of the newly formed Second Virginia Regiment, with a commission as lieutenant colonel.
In 1758, the governor assigned both Virginia regiments to regular British Army Brigadier General John Forbes, who planned to march from Philadelphia westward and take Fort Duquesne in the western frontier. On November 12, while on patrol from Fort Ligonier to repel French and Indian raids, the 2nd Virginia accidentally engaged Washington and the 1st Virginia in a heavy fog and at night. Two officers and 38 men were killed or wounded in the friendly fire incident.[9]
After the war, Mercer accepted appointment as Assistant Deputy Quartermaster-General for Maryland and Virginia (1759). Then, in 1761, Frederick County voters elected him as one of their two representatives in the House of Burgesses together with George Washington.[10] During this time, Mercer also speculated in Ohio River Valley lands in his own right. However, he was not re-elected as a Burgess.
Mercer had sailed to England as the Ohio Company of Virginia's agent, and while there accepted appointment as royal Stamp Collector for Maryland and Virginia. The Stamp Act (one of the Intolerable Acts) was a British law to recoup funds spent on the French and Indian War – and highly unpopular in Virginia. When Mercer arrived in Williamsburg in late October 1765 to attend the General Court, he experienced violent protests as well as condemnation in the Virginia Gazette. He resigned as tax collector and arranged for the stamps to be kept aboard a royal warship, and his brother James' support prevented physical injury.[11][12] Mercer was also later appointed Governor of North Carolina, but never assumed that position.
Before his father's death in 1768, Mercer returned to England as the Ohio Company's agent. He received a full share when he arranged for the Ohio Company to merge with the Vandalia Company in 1770 (creating the Grand Ohio Group) while the remaining Ohio Company shareholders split two shares, though he continued to pester George Mason as the Ohio Company treasurer for funds.[13]
Mercer also married and was widowed in England, where he remained as a Loyalist during the American Revolutionary War.[14] He died in London in 1784.