Germacrene A hydroxylase
Class of enzymes
From Wikipedia, the free encyclopedia
Germacrene A hydroxylase (EC 1.14.14.95) is an enzyme with systematic name (+)-germacrene-A,NADPH:oxygen oxidoreductase (12-hydroxylating).[1] It catalyses a sequence of three oxidation reactions.[2] The first converts (+)-germacrene A to an alcohol by addition of a hydroxy group:
,4,11(13)-trien-12-ol.svg)
-germacrene_A.svg)
| Germacrene A hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.95 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Germacrene A hydroxylase is a cytochrome P450 protein containing heme. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate. After two further oxidation steps, the product is germacrene A acid.[3]
-germacrene_A_acid.svg)
The product is further converted in chicory plants to a sesquiterpene lactone.[3]
