Born in Gela, Cacioppo graduated as a surveyor in 1983, and practiced for ten years.[1][2] He made his official debut as a stand-up comedian in 1992, with the monologue Porca miseria.[1] Moved to Bologna, he won several comedy contests, and in 1994, he made his television debut as a guest on the Maurizio Costanzo Show.[1]
After several television appearences, Cacioppo had his breakout in 1998, thanks to his partecipation in the Canale 5 variety show Zelig.[1] The same year, he made his film debut in That's Life.[2] His television credits include the variety shows Mai dire lunedì, Colorado café, and Che tempo che fa.[2][3]