Glufimet

Glufimet (developmental code name RGPU-238), also known as dimethyl 3-phenylglutamate hydrochloride, is a derivative of glutamic acid (glutamate) which was developed in Russia and is related to the γ-aminobutyric acid (GABA) derivative phenibut (3-phenyl-GABA).^[1][2][3][4] It contains phenibut and glycine fragments in its chemical structure, has been described, as a "GABA precursor", and is said to modulate the GABA and nitric oxide (NO) systems and to have antioxidant activity.^[1][2][3][4] It has been suggested that metabotropic glutamate receptors may also play a role in the mechanism of action of glufimet.^[4] Stress-protective effects have been described for glufimet in animals.^[1][2][3]

Other namesRGPU-238; Dimethyl 3-phenylglutamic acid hydrochloride; Dimethyl 3-phenylglutamate hydrochloride; 1,5-Dimethyl (2S)-2-amino-3-phenylpentanedioate hydrochloride

CAS Number

• 651321-95-8

PubChem CID

• 78064435

ChemSpider

• 9646572

Quick facts Clinical data, Other names ...

Glufimet

Clinical data
Other names	RGPU-238; Dimethyl 3-phenylglutamic acid hydrochloride; Dimethyl 3-phenylglutamate hydrochloride; 1,5-Dimethyl (2S)-2-amino-3-phenylpentanedioate hydrochloride
Identifiers
IUPAC name dimethyl 2-amino-3-phenylpentanedioate;hydrochloride
CAS Number	651321-95-8
PubChem CID	78064435
ChemSpider	9646572
CompTox Dashboard (EPA)	DTXSID00799548
Chemical and physical data
Formula	C13H18ClNO4
Molar mass	287.74 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC(=O)CC(C1=CC=CC=C1)C(C(=O)OC)N.Cl
InChI InChI=1S/C13H17NO4.ClH/c1-17-11(15)8-10(12(14)13(16)18-2)9-6-4-3-5-7-9;/h3-7,10,12H,8,14H2,1-2H3;1H Key:YYGZEJCVUMTAMY-UHFFFAOYSA-N

Close