Glutamate 5-kinase
Enzyme
From Wikipedia, the free encyclopedia
Glutamate 5-kinase (EC 2.7.2.11) is an enzyme that catalyzes the chemical reaction
| Glutamate 5-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Glutamate 5-kinase tetramer, Burkholderia thailandensis | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.2.11 | ||||||||
| CAS no. | 54596-30-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme characterised from Escherichia coli, converts L-glutamic acid, to L-γ-glutamyl phosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP). The reaction is part of the biosynthesis of the amino acid, proline.[1]
The product can spontaneously cyclise to (S)-pyroglutamic acid by loss of the phosphate group (Pi):[2]
-Pyroglutamic_acid_Structural_Formulae.png)
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. The systematic name of this enzyme class is ATP:L-glutamate 5-phosphotransferase. Other names in common use include ATP-L-glutamate 5-phosphotransferase, ATP:gamma-L-glutamate phosphotransferase, gamma-glutamate kinase, gamma-glutamyl kinase, and glutamate kinase.[2]
